Microlytic was founded in 2006 by Dr. Morten Sommer, an expert in the development of microfluidic devices for protein crystallography. The company is a commercial provider of forward thinking laboratory devices and consumables for the structural biology marketplace. Microlytic provides a portfolio of innovative products for enhancing the effectiveness of structural biology laboratories by helping to solve the major problem in structural biology: crystal formation.

The company’s flagship product, the Crystal Former, represents the first microfluidic platform to allow users to go from crystallization screen to structure using a single device. By re-engineering the liquid-liquid diffusion methodology, a time-tested and proven approach to protein crystallization, Microlytic has brought the following advantages to our customers:

  • Ability to simplify any crystallization workflow by streamlining their crystallization trials
  • Increased productivity through enhanced efficiency of the screening process, expansive coverage of crystallization space, and automation of capillary crystallization via any available liquid handler
  • A highly cost-effective solution to their crystallography needs which enhances their success and moves their scientific endeavors forward efficiently.

Microlytic develops and provides technologies to enable scientists to screen fewer discrete crystallization conditions while increasing the probability of crystallization success.

In addition to liquid-liquid diffusion, the company offers a suite of 384 crystallization conditions designed to maximize the productivity of vapor diffusion, the MCSG suite. This is accomplished through an assembly of the most productive protein crystallization conditions as identified through a decade of high throughput screening for more than 40,000 diverse protein targets at the Midwest Center for Structural Genomics. This two-pronged approach offers a greater diversity of starting crystallization conditions than would likely be achieved by using single-method crystallization strategies. This strategy identifies different crystal morphologies than those generated via single method paradigms, satisfying an important need of the structural biology research community.

We foster a collaborative, cooperative relationship with our customers, focused on their success that includes the ability to develop custom solutions and structural biology services for our customers’ needs.