Products and Services for Crystallography, from Crystallographers.

Microlytic is a company composed entirely of persons with extensive experience in the art of protein crystallography. As a result, we understand firsthand the needs of scientists attempting to grow crystals. We have applied our expertise to enable our customers to advance their research by offering solutions to their protein crystallography challenges. Throughout the entire process of interacting with Microlytic, our customers work with Ph.D. level scientists who have extensive and in-depth understanding of crystallography and processes for optimizing results and increasing throughput (such as the use of various robots for automating the process). From sales, through support and ongoing technology development and updates, our customers can be confident that Microlytic understands their challenges, speaks their language and will be available and able to help them as needed: as peers.

Founder and CEO

Morten Sommer, M.Sc., PhD, is the developer of the technology and the founder of Microlytic, LLC. He has been working on microfluidic devices for protein crystallization over the past decade at Microlytic, the California Institute for Technology and the University of Copenhagen. He is the inventor on over 10 patents and patent applications within the field of microfluidics and protein crystallization.

At California Institute of Technology, Morten co-invented the use of multi-layer soft lithography devices for protein crystallization. He co-developed the use of microfluidic formulators for experimental mapping of protein phase diagrams enabling targeted and rational approaches to protein crystallization. Subsequently Morten developed injection molded microfluidic technology for liquid-liquid diffusion based crystallization which led to the Crystal Former and the formation of Microlytic which he founded in 2006.

Morten is a Professor of Systems Biology at the Technical University of Denmark and has received various scientific awards, including the Research excellence prizes from the Hartmann Foundation and the lb Henriksen Foundation. He holds a M.Sc. in Physics and Biophysics from the University of Copenhagen and a Ph.D. in Biophysics from Harvard University.

Manager of Commercial Operations

Melanie Adams-Cioaba, Ph.D., joined Microlytic in 2010 and oversees all aspects of the company’s operations from the Microlytic’s office in Massachusetts. During her tenure at Microlytic, she has been directly involved product development, technical support, marketing, production and sales. Melanie obtained her Ph.D. at Queen's University in Canada, followed by post-doctoral fellowships at The Scripps Research Institute (La Jolla) and the Structural Genomics Consortium at Toronto. Her research topics have spanned numerous protein families, including a variety of domains of unknown function, integral membrane proteins and numerous epigenetics targets. With more than 450 citations and experience in numerous research environments, Melanie's current interests have focused on a common challenge facing all crystallography groups: widening the crystallization bottleneck through optimization of protein crystallization pipelines and the development of products to ensure the high output of crystallization trials thus generating higher crystallization success with less crystallization screening.

Melanie has been the recipient of numerous awards and fellowships, including multiple fellowships from the Natural Science and Engineering Research Council and the Governor General's Academic Gold Medal.

Application Scientist

Kateryna Podzelinska, Ph.D., is the lead application scientist at Microlytic. After receiving a BS Degree from Queen’s University she performed undergraduate research work in a crystallography lab where she developed a passion for deciphering the structures of important proteins. In her doctoral program she pursued a challenging project on determining the structure of human cancer proteins. Arduous research and experimenting with a variety of techniques to generate these structures enhanced her skill set in protein engineering, purification methodology and extensive testing of conditions for crystallization. In subsequent bacterial work she obtained structures of two proteins and discovered a novel cofactor modification in one of these. She has won multiple awards, has 5 depositions in the Protein Data Bank, and is first author on three papers and co-author on others. Her passion for science, problem solving and teaching has led to her position at Microlytic where she has been since 2010. In her role she supports customers, develops protocols and conducts workshops/tutorials to educate Microlytic’s customers.

Technical Key Account Manager-Eastern US

Eddie Pryor, Ph.D., earned his BS Degree in Computer Science from Quinnipiac University where he did research developing methods for creating phylogenetic trees for protein sequences. He joined the Computer Science department at Wake Forest University in the computational biophysics group where his research involved developing algorithms to search all known protein structures and find related structures based on the conformation of their active site.

He received his Ph.D. from The Wake Forest School of Medicine where he elucidated virulence gene regulation by the pathogenic bacterium Pseudomonas aeruginosa. Eddie determined the crystal structure of the transcriptional regulator AmrZ, in complex with an 18 base pair DNA duplex which led to understanding how the three domains of AmrZ work in concert to activate and repress genes.

Eddie did postdoctoral training at the University of Virginia where he worked as a member of the PSI-Biology funded Membrane Protein Structural Biology Consortium. As a member of this group, Eddie crystallized and determined the structure of the integral membrane CAAX protease, Ste24p.

Technical Key Account Manager-Western US

Jean Xu, Ph.D., graduated from Imperial College, London with a B.Sc. degree in Biochemistry and obtained her D.Phil (Ph.D) in Biochemistry at the University of Oxford. Her graduate research focused on the biophysical characterization of influenza viral surface proteins. She attended The Scripps Research Institute at La Jolla, California, as an external graduate student, where she determined the X-ray crystal structures of proteins that are critical drug targets for combating influenza virus.

Following the completion of her doctoral work, Jean worked at Emory University as a post-doctoral fellow where she studied the fundamental mechanisms governing the immunological memory for long-term protection. Jean has professional experience in a diverse range of research disciplines such as Molecular Biology, Biochemistry and Protein Chemistry. She has published in many international peer-reviewed journals. Jean’s long-term career interests lie in the area of technology commercialization and business development.